Morphological changes of sclera in rats with experimental myopia.
نویسندگان
چکیده
منابع مشابه
Reduced extracellular matrix in mammalian sclera with induced myopia
The purpose of this study was to learn whether visual form deprivation, which produces myopia in the deprived eye, alters the scleral extracellular matrix in tree shrew, a mammal closely related to primates. Axial myopia was induced in 10 tree shrews by monocular deprivation imposed with a translucent diffuser. The other eye in each animal was an untreated control. After 21 days of deprivation ...
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PURPOSE Transforming growth factor-beta2 (TGF-beta2), basic fibroblast growth factor (bFGF), and fibromodulin (FMOD) are important extracellular matrix components of the sclera and have been shown to be associated with the development of high myopia. Our aim was to examine the association between myopia and the polymorphisms within TGF-beta2, bFGF, and FMOD. METHODS The study group comprised ...
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Devices that degrade vision were applied to the left eyes of 3-day old chicks. The dome device affected the entire visual field, and the arch device, only the lateral field. Control chicks wearing a circumorbital ring and untreated chicks were also examined. The dome device produced -15D and the arch device -4D of mean refractive error, while the ring and untreated chicks were emmetropic. Morph...
متن کاملChanges in protein profiles of guinea pig sclera during development of form deprivation myopia and recovery
PURPOSE To investigate changes in protein profiles of posterior sclera in guinea pigs during development of form deprivation myopia and recovery. METHODS Three groups of guinea pigs (developing form deprivation myopia, recovering from the myopia and normal control) were evaluated for protein profiles of the posterior sclera using two-dimensional gel electrophoresis. Protein spots with a diffe...
متن کاملStructural and ultrastructural changes to the sclera in a mammalian model of high myopia.
PURPOSE The development of high myopia is associated with scleral thinning and changes in the diameter of scleral collagen fibrils in humans. In the present study, the association between these scleral changes and the losses in scleral tissue that have previously been reported in animal models were investigated to determine the relationship between changes in collagen fibril architecture and th...
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ژورنال
عنوان ژورنال: Morphologia
سال: 2014
ISSN: 1997-9665
DOI: 10.26641/1997-9665.2014.2.72-76